This protects the ClearOS admin panel (Webconfig). Once you are logged in, you can use the Dynamic Firewall to temporarily permit access to other apps (SSH, VPN, etc)
yum --enablerepo=clearos-updates-testing,clearos-contribs-testing install app-two-factor-auth
The information about the configuration is at /etc/clearos/two_factor_auth.conf (useful if you can't log in via the ClearOS admin panel because you are not receiving the emails)
If you need to add more than one email address (which is typical for the root account, just create a redirect ( rootmfa at example.org -> joe at example.org and jane at example.org and use mail forwarding.
You can also forward emails to SMS but be aware that SMS-based two-step verification is no longer recommended by NIST